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Amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) is a disease of the nervous system. It weakens the muscles and affects nerve cells in the brain and spinal cord. As it progresses, motor neurons deteriorate. The brain loses the ab. Need information about ALS or support services for yourself or a loved one with ALS? These organizations can help connect you with the resources you need and bring you up to date on research into the causes and treatments for ALS. The follo. Amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's disease) is a rare disease that damages the nerves that control muscles. Over time, the muscles gradually weaken, twitch (fasciculate), and atrophy, and the brain loses the abilit.